Thesis (M.Sc.) -- University of Toronto, 1998.
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
|Pagination||2 microfiches : negative. --|
Traditional case-control studies provide a powerful and efficient method for evaluation of association between candidate genes and disease. The sampling of cases from multiplex pedigrees, rather than from a catchment area, can increase the likelihood that genetic cases are by: (). Pulver AE: Analysis of case-control/family sampling design. Genet Epidemiol (). Schaid DJ: Evaluation of candidate genes in case-control studies: a . Comparing strategies for evaluation of candidate genes in case-control studies using family data The goal of this analysis is to compare different test strategies for genetic association in case-control studies using related individuals. and apply these methods to a candidate gene dataset of Genetic Analysis Workshop 15 from the. Traditional case-control studies provide a powerful and efficient method for evaluation of association between candidate genes and disease. The sampling of cases from multiplex pedigrees, rather than from a catchment area, can increase the likelihood that genetic cases are selected. However, use of all the related cases without accounting for their biological relationship can increase the type.
Candidate-gene studies depend on a set of markers based on a priori hypothesis about the role of a selected gene, or a group of pathway-related genes, on a phenotype. The single-gene approach offers the advantage that highly relevant genes can be prioritized and tested first. The early documentation of the functional roles of several candidate genes in model species (Zhu and Zhao ) allowed ecological studies testing hypotheses relative to the roles of such genes on. Genetic Evaluation Genetic evaluation includes a detailed medical history including the cancer and pre-neoplastic diagnoses, the construction of a three to four generation family tree, physical examination, risk assessment, and consideration of genetic testing, including a full discussion of possible genetic discrimination. Family Studies Family studies are another way of investigating genetic links in offending behaviour. Brunner et al. () conducted an analysis of a large family in the Netherlands, a number of which had been responsible for various counts of anti-social and criminal behaviour including attempted rape, exhibitionism and arson.
Gene-based tests to study the combined effect of rare variants towards a particular phenotype have been widely developed for case-control studies, but their evolution and adaptation for family-based studies, especially for complex incomplete families, has been slower. In this study, we have performed a practical examination of all the latest gene-based methods available for family-based study. T1 - Evaluation of candidate genes in case-control studies. T2 - A statistical method to account for related subjects. AU - Slager, S. L. AU - Schaid, D. J. PY - /1/1. Y1 - /1/1. N2 - Traditional case-control studies provide a powerful and efficient method for evaluation of association between candidate genes and disease. When the direct impact of candidate genes for a variety of traits was reviewed in GWA studies, very little effect was identified (Siontis, et al., ). It is quite possible that the gene–environment hypothesis will never be supported, or only be shown to have a . One commonly used technique to identify genetic risk factors for complex disorders such as alcoholism is the candidate gene approach, which directly tests the effects of genetic variants of a potentially contributing gene in an association study.